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10 May 2017
Naoual Benhmidou1, Fadoua Rais1, Fadila Kouhen2, Abdelhak Maghous1, Hasna Loughlimi1, Khadija Bellahammou3, Hanan Elkacemi1, Tayeb Kebdani1, Sanaa Elmajjaoui1, Noureddine Benjaafar1 1)
10 May 2017
Khadija Bellahammou1, Asmaa Lakhdissi1,
10 May 2017
Khaled Moursy Salama1, Monira T.
02 April 2017
Bardia Bidarmaghz, Ryo Mizumoto, Rasika

HORMONE THERAPY IN ADVANCED ER+/HER2- NEGATIVE BREAST CANCER WITH PI3K INHIBITORS: A REVIEW OF THE LITERATURE

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Ivan Inkov1, Desislava Penkova2, George Baytchev1, Zdravko Kamenov3, Mila Kayriakova3, Dimo Manov3

1) Department Of Thoracic Surgery, Military Medical Academy, Sofia, Bulgaria.

2) Novartis Oncology; Novartis Pharmaceutical Corporation, Sofia, Bulgaria.

3) Medical University of Sofia, Sofia, Bulgaria

Disclosure: The author has declared no conflicts of interest.

Accepted: 30.04.16

Citation: http://dx.doi.org/10.5455/ijsm.pi3kinhibitorbreastcancer

Abstract:

Breast cancer is a heterogenous disease, showing as several different clinical and histologic types. Most of breast cancers express hormone receptors for estrogen and progesterone, which are considered as estrogen receptor-positive and progesterone-receptor-positive, respectively.

Endocrine therapy was the first class of target-directed therapy approved for treating breast cancer and is still very important for the treatment of HR+ breast cancer because of its effectiveness and good toxicity profile. It targets receptor-mediated signaling pathways implicated in cell survival and proliferation, such as those mediated by hormone receptors. Although these approaches have improved the management of advanced breast cancer, many patients either fail to respond to initial therapy (primary or de novo resistance) or eventually become resistant to treatment (secondary or acquired resistance). To expand the use of existing endocrine treatments and their efficiency, new methods are needed. Such new approaches would boost the benefit of existing endocrine therapy by extending time to disease progression, avoiding or overcoming resistance to endocrine treatment, and delaying the use of chemotherapy.

This article will review the central role of the PI3K inhibitors in driving ER+/HER2- breast tumors. Also, schemes to combine pathway inhibitors with endocrine therapy for better patient outcome, and approaches to identify patient populations that would benefit most from inhibition of the PI3K/AKT/mTOR pathway will be assessed.

Abstract & Fulltext

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