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05 August 2016
Ivan Inkov1, Desislava Penkova2, George Baytchev1, Zdravko Kamenov3, Mila Kayriakova3, Dimo Manov3 1) Department Of Thoracic Surgery, Military Medical Academy, Sofia, Bulgaria. 2) Novartis

CALCIUM AND VITAMIN D STATUS IN MORBIDLY OBESE PATIENTS AND IN PATIENTS AFTER BILIOPANCRETIC DIVERSION/DUODENAL SWITCH

Natalya Mazurina1, Ekaterina Troshina1, Natalya Ogneva1, Yury Yashkov2, Alexander Iliyn1, Galina Melnichenko1, Ivan Dedov1

1) Endocrinology Research Center, Moscow, Russian Federation.

2) The Center for Endosurgery and Lithotripsy, Moscow, Russian Federation.

Disclosure: The author has declared no conflicts of interest.

Received: 01.07.16 Accepted: 17.08.16

Citation: 10.5455/ijsm.vitamin-d-biliopancreatic-diversion

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Abstract:

Objective: The objective was to estimate the prevalence of inadequate vitamin D status and secondary hyperparathyroidism (SHPT) in morbidly obese patients and in patients who underwent biliopancreatic diversion/duodenal switch surgery (BPD/DS)
Design: 3 groups were included in the cross-sectional comparative study: group 1 - morbidly obese (MO) patients with BMI > 40 and without type 2 diabetes mellitus (n=22), group 2 – patients in the long-term period after BPD/DS (n=23); group 3 – healthy normal weight controls (n=22).
Results: 25(OH)D levels were significantly different in the controls (21.8 ng/dl), in the MO (8.8 ng/dl) and in the BPD/DS patients (8.6 ng/dl). Parathyroid hormone (PTH) elevation was found in 4 (18%) MO patients, in 12 (52 %) patients after BPD/DS, and was not detected in the control group. The frequency of SHPT was significantly higher in the operated group (52 %) in comparison with the MO group (18 %) (р=0.029).
Conclusions: Vitamin D deficiency and secondary hyperparathyroidism are significantly more prevalent in MO patients than in normal weight subjects. In the long-term period after BPD secondary hyperthyroidism is more frequent than in MO and is not always accompanied by vitamin D depletion. Special attention should be paid for adequate control of calcium metabolism and supplementation by calcium and vitamin D.

Keywords: obesity, bariatric surgery, vitamin D, secondary hyperparathyroidism


How to Cite this Article

Bibliography

Mazurina, N., Troshina, E., Ogneva, N., Yashkov, Y., Iliyn, A., Melnichenko, G. and Dedov, I. (2016) ‘Calcium and vitamin D status in morbidly obese patients and in patients after biliopancretic diversion/duodenal switch’, International Journal of Surgery and Medicine, 2(4), pp. 202–207. doi: 10.5455/ijsm.vitamin-d-biliopancreatic-diversion.

Citations, Quotes & Annotations

Mazurina, N., Troshina, E., Ogneva, N., Yashkov, Y., Iliyn, A., Melnichenko, G. and Dedov, I. (2016) ‘Calcium and vitamin D status in morbidly obese patients and in patients after biliopancretic diversion/duodenal switch’, International Journal of Surgery and Medicine, 2(4), pp. 202–207. doi: 10.5455/ijsm.vitamin-d-biliopancreatic-diversion.
(Mazurina et al., 2016)
Last modified onSunday, 01 January 2017 13:25

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