1) Department of Oral Surgery, Medical University-Plovdiv, Bulgaria.
2) Department of Microbiology and Immunology, Medical University - Plovdiv, Bulgaria.
3) Department of Analytical Chemistry and Computer Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria.
Disclosure: The author has declared no conflicts of interest.
Received: 20.04.16 Accepted: 21.05.16
Objective: The objective of this study is to determine the change in IL-6 serum levels in patients undergoing preemptive analgesia and surgical removal of an impacted mandibular third molar.
Study Design: This is a prospective, double-blind, placebo-controlled study in 80 patients who had an atypical extraction of an impacted mandibular third molar.
Results: After surgical removal of impacted mandibular third molars, elevated levels of IL-6 in the early postoperative period were found, and the highest level was 14 pg/ml.
Conclusion: Postoperative IL-6 levels rise regardless of the medication used for preemptive analgesia. In the group treated with nimesulide, a trend to reducing IL-6 levels was observed, but further study in a larger number of patients is needed.
Abstract & Fulltext
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