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CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS

Deyan Zdravkov Neychev1, Irina Stanimirova2, Kiril Kostov Simitchiev3, Mariana Murdjeva2, Dimitar Atanasov1

1) Department of Oral Surgery, Medical University-Plovdiv, Bulgaria.

2) Department of Microbiology and Immunology, Medical University - Plovdiv, Bulgaria.

3) Department of Analytical Chemistry and Computer Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria.

Disclosure: The author has declared no conflicts of interest.

Received: 20.04.16 Accepted: 21.05.16

Citation: doi:10.5455/ijsm.mandibular-third-molar

Abstract:

Objective: The objective of this study is to determine the change in IL-6 serum levels in patients undergoing preemptive analgesia and surgical removal of an impacted mandibular third molar.
Study Design: This is a prospective, double-blind, placebo-controlled study in 80 patients who had an atypical extraction of an impacted mandibular third molar.
Results: After surgical removal of impacted mandibular third molars, elevated levels of IL-6 in the early postoperative period were found, and the highest level was 14 pg/ml.
Conclusion: Postoperative IL-6 levels rise regardless of the medication used for preemptive analgesia. In the group treated with nimesulide, a trend to reducing IL-6 levels was observed, but further study in a larger number of patients is needed.

Abstract & Fulltext

Last modified onMonday, 05 September 2016 18:53

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