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04 December 2016
At the end of 2016, the International Journal of Surgery and Medicine is indexed by Index Copernicus. The journal has secured an ICV value of 86.35 for the year 2015. This value indicates high
22 January 2017
Khadija Bellahammou1, Asmaa Lakhdissi1,
02 February 2016
D. Penchev1, S. Maslyankov3, V.
22 January 2017
Amel Harzallah1, Hayet Kaaroud1, Hamida

NEUROBLASTOMA IN AN ADULT: A CASE REPORT OF A RARE ENTITY WITH A SUMMARY REVIEW

Fadoua Rais1, Naoual Benhmidou, Ghizlane Rais2, Abdelhak Maghous1, Hasnaa Loughlimi1, Fadila Kouhen1, Jihane Aarab1, Khadija Bellahammou2, Mouna Khmou3, Karima Laadam3, Fouad Zouaidia3, Sanaa Elmejjaoui1, Tayeb Kebdani1, Hanan Elkacemi1, Noureddine Benjaafar1.

1) Department of Radiotherapy, National Institute of Oncology, Mohammed V University In Rabat, Morocco.

2) Department of Oncology, National Institute of Oncology, Rabat, Morocco.

3) Department of Pathology, Ibn Sina Hospital, Rabat, Morocco.

Disclosure: The author has declared no conflicts of interest.

Received: 24.12.15 Accepted: 10.02.16

Citation: 10.5455/ijsm.neuroblastoma

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Abstract:

Neuroblastoma is a very uncommon neoplasm in adulthood. It occurs almost exclusively in children younger than 10 years (More than 90% of cases). We report the case of a healthy 40-year-old male who complained of a right flank pain in 2010. Clinical examination revealed an enormous abdominal mass involving the adrenal gland as showed at abdominal CT scan. The patient underwent a surgical en-bloc excision of the right adrenal mass, after a laborious dissection of the tumor. Histological and immunohistochemical findings were suggestive of a neuroblastoma. Adjuvant treatment was not indicated since the complete gross excision of the tumor was performed, and subsequently the patient was considered stage 1 disease and because of the unavailability of MYCN status, necessary for achieving risk group stratification and a risk-adapted strategy. The patient remained in good local control, until January 2015 when he accused a locoregional and metastatic relapse consisting of two new para-renal masses and magma of celiac adenomegalies extending into the mediastinum. As the mass was considered unresectable, therapeutic decision of administrating neoadjuvant chemotherapy, followed by local treatment (surgery and / or radiotherapy) based on tumor response was taken. Given the bad tumor response to systemic treatment, a palliative radiotherapy was instaured. Currently the patient is two months after the end of radiation with mild clinical improvement. The purpose of presenting this case is not only to report an uncommon malignancy in adulthood, but also to raise awareness among clinicians adding this clinical entity as a differential diagnosis when a retroperitoneal mass is identified. We also conducted a literature review to enhance clinicians’ acknowledgment about the management of this rare entity in adults.

Keywords: Neuroblastoma, Adult, retroperitoneal mass


How to Cite this Article

Bibliography

Rais, F., Benhmidou, N., Rais, G., Maghous, A., Loughlimi, H., Kouhen, F., Aarab, J., Bellahammou, K., Khmou, M., Laadam, K., Zouaidia, F., Elmejjaoui, S., Kebdani, T., Elkacemi, H. and Benjaafar, N. (2017) ‘Neuroblastoma in an adult: A case report of a rare entity with a summary review’, International Journal of Surgery and Medicine, , p. Online First. doi: 10.5455/ijsm.neuroblastoma.

Citations, Quotes & Annotations

Rais, F., Benhmidou, N., Rais, G., Maghous, A., Loughlimi, H., Kouhen, F., Aarab, J., Bellahammou, K., Khmou, M., Laadam, K., Zouaidia, F., Elmejjaoui, S., Kebdani, T., Elkacemi, H. and Benjaafar, N. (2017) ‘Neuroblastoma in an adult: A case report of a rare entity with a summary review’, International Journal of Surgery and Medicine, , p. Online First. doi: 10.5455/ijsm.neuroblastoma.
(Rais et al., 2017)

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